The Tick: The Complete Edlund by Ben Edlund
A cult classic comic in collected form! If you remember the old, short-lived Saturday morning cartoon of the same name, or the even shorter-lived live-action sitcom of the same name, you'll love this. The publisher (New England Comics) has been releasing Tick collections, and they're all fun, but if you can only have one, this is the one to have - by Ben Edlund, the creator himself.
Much darker and funnier than anything you've seen on TV, it's framed in almost a sort of One Flew Over The Cuckoos Nest narrative at the beginning that makes you suspect that while you follow the Tick on all his misadventures, fighting Ninja, saving The City, well, he may just be in a mental ward lock up someplace and we're just seeing his crazed fantasies.